Selectivity and Promiscuity in Eph Receptors

Ephrins and Eph Receptors

chemorepulsive factors. Integrin heterodimers are primary ECM receptors, which can exist in different functional states with respect to their affinity or avidity for ECM proteins (11, 35), and directed cell motility on ECM is promoted by targeted localization of high-affinity integrins at the leading edge of migrating cells (40). There is now mounting evidence that both chemoattractant and chem...

Ephrins and Eph Receptors

chemorepulsive factors. Integrin heterodimers are primary ECM receptors, which can exist in different functional states with respect to their affinity or avidity for ECM proteins (11, 35), and directed cell motility on ECM is promoted by targeted localization of high-affinity integrins at the leading edge of migrating cells (40). There is now mounting evidence that both chemoattractant and chem...

Eph receptors and ephrins.

Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility. Eph signaling is crucial for the development of many tissues and organs including the nervous and cardiovascular systems. Both Ephs and ephrins are membrane-bound and their interactions at sites of ...

EPH receptors in cancer.

EPH receptors and their ephrin ligands constitute the largest sub-family of receptor tyrosine kinases (RTKs) and are components of cell signaling pathways involved in animal development. The ability of the EPH/ephrin guidance system to position cells and modulate cell morphology underlies their various roles in development. In addition, EPH signaling plays an important role in oncogenic process...

Eph receptors as oncotargets